Reinhard Schinzel Selected Research

4-amino-tetrahydrobiopterin

12/2020	Correction to: Efficacy of Ronopterin (VAS203) in Patients with Moderate and Severe Traumatic Brain Injury (NOSTRA phase III trial): study protocol of a confirmatory, placebocontrolled, randomised, double blind, multi-centre study.
1/2020	Efficacy of Ronopterin (VAS203) in Patients with Moderate and Severe Traumatic Brain Injury (NOSTRA phase III trial): study protocol of a confirmatory, placebo-controlled, randomised, double blind, multi-centre study.
1/2019	Effects of the nitric oxide synthase inhibitor ronopterin (VAS203) on renal function in healthy volunteers.
5/2015	Endothelial nitric oxide synthase mediates arteriolar vasodilatation after traumatic brain injury in mice.
10/2014	Nitric oxide synthase inhibition with the antipterin VAS203 improves outcome in moderate and severe traumatic brain injury: a placebo-controlled randomized Phase IIa trial (NOSTRA).
11/2009	The novel nitric oxide synthase inhibitor 4-amino-tetrahydro-L-biopterine prevents brain edema formation and intracranial hypertension following traumatic brain injury in mice.

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Reinhard Schinzel Research Topics

Disease

5	Traumatic Brain Injuries (Traumatic Brain Injury) 12/2020 - 11/2009
2	Intracranial Hypertension 05/2015 - 11/2009
2	Coronary Artery Disease (Coronary Atherosclerosis) 05/2009 - 02/2008
2	Renal Insufficiency (Renal Failure) 06/2005 - 02/2003
2	Liver Cirrhosis (Hepatic Cirrhosis) 06/2005 - 01/2002
1	Body Weight (Weight, Body) 01/2019
1	Wounds and Injuries (Trauma) 05/2015
1	Acute Kidney Injury (Acute Renal Failure) 10/2014
1	Hyperaldosteronism (Conn Syndrome) 12/2011
1	Cardiovascular Diseases (Cardiovascular Disease) 12/2010
1	Brain Edema (Cerebral Edema) 11/2009
1	Alzheimer Disease (Alzheimer's Disease) 11/2003
1	Neuroblastoma 11/2003
1	Diabetes Complications 09/2003
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 09/2003
1	Hyperhomocysteinemia 06/2003
1	Proteinuria 03/2003
1	Acute-Phase Reaction 07/2002
1	Inflammation (Inflammations) 07/2002
1	Chronic Kidney Failure (Chronic Renal Failure) 06/2002
1	Liver Diseases (Liver Disease) 01/2002

Drug/Important Bio-Agent (IBA)

7	Advanced Glycation End ProductsIBA 06/2005 - 01/2002
6	4-amino-tetrahydrobiopterinIBA 12/2020 - 11/2009
3	Proteins (Proteins, Gene)FDA Link 06/2005 - 06/2003
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 10/2014 - 11/2009
2	Nitric Oxide Synthase (NO Synthase)IBA 10/2014 - 11/2009
2	N(6)-carboxymethyllysine (carboxymethyllysine)IBA 09/2003 - 01/2002
1	sapropterin (tetrahydrobiopterin)FDA Link 01/2019
1	Phosphates (Orthophosphate)IBA 05/2015
1	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 05/2015
1	CalciumIBA 12/2011
1	NADPH Oxidases (NAD(P)H oxidase)IBA 12/2011
1	AldosteroneIBA 12/2011
1	Pharmaceutical PreparationsIBA 12/2010
1	Cyclic NucleotidesIBA 12/2010
1	Niacin (Nicotinic Acid)FDA LinkGeneric 05/2009
1	Clopidogrel (Plavix)FDA Link 02/2008
1	AldehydesIBA 06/2005
1	Ethanol (Ethyl Alcohol)IBA 06/2005
1	Adenosine Triphosphate (ATP)IBA 11/2003
1	Glucose (Dextrose)FDA LinkGeneric 11/2003
1	Amyloid beta-PeptidesIBA 11/2003
1	Lactic Acid (Lactate)FDA LinkGeneric 11/2003
1	Triglycerides (Triacylglycerol)IBA 09/2003
1	LipidsIBA 09/2003
1	Biological ProductsIBA 09/2003
1	CholesterolIBA 09/2003
1	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 06/2003
1	A-factor (Streptomyces)IBA 03/2003
1	CreatinineIBA 03/2003
1	salicylhydroxamic acid (SHAM)IBA 03/2003
1	DNA (Deoxyribonucleic Acid)IBA 02/2003
1	Acute-Phase Proteins (Acute-Phase Protein)IBA 07/2002
1	AlbuminsIBA 01/2002

Therapy/Procedure

1	Therapeutics 12/2011
1	Nephrectomy 03/2003
1	Renal Dialysis (Hemodialysis) 07/2002
1	Liver Transplantation 01/2002